Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
|Original language||American English|
|Number of pages||6|
|Journal||American Journal of Tropical Medicine and Hygiene|
|State||Published - 1 Mar 2009|
Gavidia, C. M., Gonzalez, A. E., Lopera, L., Jayashi, C., Angelats, R., Barron, E. A., Ninaquispe, B., Villarreal, L., Garcia, H. H., Verastegui, M. R., & Gilman, R. H. (2009). Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep. American Journal of Tropical Medicine and Hygiene, 367-372.