Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

A. Santa Maria, A. Lopez, M. M. Diaz, J. Albán, A. Galán De Mera, J. A. Vicente Orellana, J. M. Pozuelo

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45 Scopus citations


Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.
Original languageAmerican English
Pages (from-to)183-187
Number of pages5
JournalJournal of Ethnopharmacology
StatePublished - 1 Aug 1997


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