Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

A. Santa Maria; A. Lopez; M. M. Diaz; J. Albán; A. Galán De Mera; J. A. Vicente Orellana; J. M. Pozuelo

doi:10.1016/S0378-8741(97)00067-6

Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

A. Santa Maria, A. Lopez, M. M. Diaz, J. Albán, A. Galán De Mera, J. A. Vicente Orellana, J. M. Pozuelo

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.

Original language	American English
Pages (from-to)	183-187
Number of pages	5
Journal	Journal of Ethnopharmacology
DOIs	https://doi.org/10.1016/S0378-8741(97)00067-6
State	Published - 1 Aug 1997

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0378-8741(97)00067-6

Cite this

@article{c75624242b6a4087b903a0ba97f29f0f,

title = "Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro",

abstract = "Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.",

author = "{Santa Maria}, A. and A. Lopez and Diaz, {M. M.} and J. Alb{\'a}n and {Gal{\'a}n De Mera}, A. and {Vicente Orellana}, {J. A.} and Pozuelo, {J. M.}",

year = "1997",

month = aug,

day = "1",

doi = "10.1016/S0378-8741(97)00067-6",

language = "American English",

pages = "183--187",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

AU - Santa Maria, A.

AU - Lopez, A.

AU - Diaz, M. M.

AU - Albán, J.

AU - Galán De Mera, A.

AU - Vicente Orellana, J. A.

AU - Pozuelo, J. M.

PY - 1997/8/1

Y1 - 1997/8/1

N2 - Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.

AB - Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0342617510&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0342617510&origin=inward

U2 - 10.1016/S0378-8741(97)00067-6

DO - 10.1016/S0378-8741(97)00067-6

M3 - Article

SN - 0378-8741

SP - 183

EP - 187

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

ER -

Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this