Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis

José W. López, Maria Cristina I. Loader, Daniel Smith, Daniel Pastorius, Marjory Bravard, Luz Caviedes, Karina M. Romero, Taryn Clark, William Checkley, Eduardo Ticona, Jon S. Friedland, Robert H. Gilman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant–TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8–26] versus 15 ppb [IQR = 12–24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10–19] at day 60). Taking this and previous evidence together, we conclude FeNO is not of value in either the diagnosis of pulmonary TB or as a marker of treatment response.

Original languageEnglish
Pages (from-to)1637-1639
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number6
DOIs
StatePublished - 2018

Bibliographical note

Funding Information:
Financial support: This work was supported by the Gates Challenge Grant; the Fogarty Foundation Fellows program of Vanderbilt University (grant number R24 TW007988 to J. W. L.) and the University of North Carolina; and the National Institutes of Health. J. S. F. and MC. I. L. are grateful for financial support from the Imperial College Biomedical Research Centre.

Funding Information:
This work was supported by the Gates Challenge Grant; the Fogarty Foundation Fellows program of Vanderbilt University (grant number R24 TW007988 to J. W. L.) and the University of North Carolina; and the National Institutes of Health. J. S. F. and MC. I. L. are grateful for financial support from the Imperial College Biomedical Research Centre.

Publisher Copyright:
Copyright © 2018 by The American Society of Tropical Medicine and Hygiene.

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