Katherine Alexandra Sota Ortecho, Javier A. Bustos, Manuela R. Verastegui, Luz Toribio, Nancy Chile, Noelia Angulo, Carla Cangalaya, Juan Calcina, Armando E. González, Robert H. Gilman, Héctor H. García

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective. To explore the feasibility of developing a sheep model of neurocysticercosis (NCC) by intracranial infection with T. solium oncospheres. Materials and methods. We carried out an experimental infection model of NCC in sheep. Approximately 10 T. solium oncospheres previously cultured for 30 days were inoculated intracranially into ten sheep. The oncospheres, in 0.1 mL of physiological saline, were injected into the parietal lobe through an 18-gauge needle. Results. After three months, granulo-mas were found in two sheep. In a third sheep we identified a 5 mm diameter cyst in the right lateral ventricle and histological evaluation confirmed that the cyst corresponded to a T. solium larva. Immuno-histochemistry with monoclonal antibodies directed against membrane components and excretory/se-cretory antigens of the T. solium cyst was also used to confirm the etiology of the found granulomas. One of them showed reactivity to the monoclonal antibodies used, thus confirming that it was a cysticercus. Conclusion. This experiment is the proof of concept that it is possible to infect sheep with cysticercosis by intracranial inoculation.

Original languageEnglish
Pages (from-to)328-335
Number of pages8
JournalRevista Peruana de Medicina Experimental y Salud Publica
Issue number3
StatePublished - 30 Sep 2022

Bibliographical note

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  • Cysticercosis source: MeSH NLM)
  • Epilepsy
  • Neurocysticercosis
  • Sheep, Taenia solium


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