A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.
Bibliographical noteFunding Information:
This paper was funded in part by the NIH grant AI 35894, an ITREID and ABC NIH — Fogarty center grant and the anonymous RG-ER fund. We appreciate the comments of Drs. C. Sterling, and J.J. Strauss and the technical support of J.B. Phu , D. Sara, and G. Sari-Cece.
- Experimental infection
- IMOA, intramuscular oncosphere assay
- Taenia solium