Experimental infection model for Taenia solium cysticercosis in swine

Manuela Verástegui; Armando González; Robert H. Gilman; César Gavidia; Néstor Falcón; Teresa Bernal; Hector Hugo Garcia

doi:10.1016/S0304-4017(00)00369-1

Experimental infection model for Taenia solium cysticercosis in swine

Manuela Verástegui, Armando González, Robert H. Gilman, César Gavidia, Néstor Falcón, Teresa Bernal, Hector Hugo Garcia

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	33-44
Number of pages	12
Journal	Veterinary Parasitology
Volume	94
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-4017(00)00369-1
State	Published - 20 Dec 2000

Bibliographical note

Funding Information:
This paper was funded in part by the NIH grant AI 35894, an ITREID and ABC NIH — Fogarty center grant and the anonymous RG-ER fund. We appreciate the comments of Drs. C. Sterling, and J.J. Strauss and the technical support of J.B. Phu , D. Sara, and G. Sari-Cece.

Keywords

Cysticercosis
Experimental infection
IMOA, intramuscular oncosphere assay
Oncosphere
Taenia solium

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title = "Experimental infection model for Taenia solium cysticercosis in swine",

abstract = "A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.",

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AU - Verástegui, Manuela

AU - González, Armando

AU - Gilman, Robert H.

AU - Gavidia, César

AU - Falcón, Néstor

AU - Bernal, Teresa

AU - Garcia, Hector Hugo

N1 - Funding Information: This paper was funded in part by the NIH grant AI 35894, an ITREID and ABC NIH — Fogarty center grant and the anonymous RG-ER fund. We appreciate the comments of Drs. C. Sterling, and J.J. Strauss and the technical support of J.B. Phu , D. Sara, and G. Sari-Cece.

PY - 2000/12/20

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N2 - A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.

AB - A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.

KW - Cysticercosis

KW - Experimental infection

KW - IMOA, intramuscular oncosphere assay

KW - Oncosphere

KW - Taenia solium

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ER -

Experimental infection model for Taenia solium cysticercosis in swine

Abstract

Bibliographical note

Keywords

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