Experimental infection model for Taenia solium cysticercosis in swine

Manuela Verástegui, Armando Emiliano Gonzalez Zariquiey, Robert H. Gilman, Cesar Miguel Gavidia Chucan, Néstor Falcón, Teresa Bernal, Hector Hugo Garcia

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)33-44
Number of pages12
JournalVeterinary Parasitology
Volume94
Issue number1-2
DOIs
StatePublished - 20 Dec 2000
Externally publishedYes

Bibliographical note

Funding Information:
This paper was funded in part by the NIH grant AI 35894, an ITREID and ABC NIH — Fogarty center grant and the anonymous RG-ER fund. We appreciate the comments of Drs. C. Sterling, and J.J. Strauss and the technical support of J.B. Phu , D. Sara, and G. Sari-Cece.

Keywords

  • Cysticercosis
  • Experimental infection
  • IMOA, intramuscular oncosphere assay
  • Oncosphere
  • Taenia solium

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