Experimental infection model for Taenia solium cysticercosis in swine

Manuela Verástegui, Armando González, Robert H. Gilman, César Gavidia, Néstor Falcón, Teresa Bernal, Hector Hugo Garcia

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)33-44
Number of pages12
JournalVeterinary Parasitology
Volume94
Issue number1-2
DOIs
StatePublished - 20 Dec 2000

Bibliographical note

Funding Information:
This paper was funded in part by the NIH grant AI 35894, an ITREID and ABC NIH — Fogarty center grant and the anonymous RG-ER fund. We appreciate the comments of Drs. C. Sterling, and J.J. Strauss and the technical support of J.B. Phu , D. Sara, and G. Sari-Cece.

Keywords

  • Cysticercosis
  • Experimental infection
  • IMOA, intramuscular oncosphere assay
  • Oncosphere
  • Taenia solium

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