Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions

E. Javier Pretell, Héctor H. García, Robert H. Gilman, Herbert Saavedra, Manuel Martinez, S. Rodriguez, C. Padilla, M. Porras, A. E. Gonzalez, M. Verastegui, C. Evans, V. C.W. Tsang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.

Original languageEnglish
Article number968
Pages (from-to)175-177
Number of pages3
JournalClinical Neurology and Neurosurgery
Volume103
Issue number3
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
Partial support was received from grants number FD-R-001107 from the Food and Drug Administration, and U19-A145431 from NIAID/NIH (USA).

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Cysticercosis
  • Neurocysticercosis
  • Praziquantel
  • Taenia solium

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