Fluorine hydrogen short contacts and hydrogen bonds in substituted benzamides

Lothar Hennig, Ketty Ayala-Leon, Jorge Angulo-Cornejo, Rainer Richter, Lothar Beyer

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A series of fluorine substituted benzamides 1-10 was synthesised and investigated by spectroscopic methods (NMR, IR, MS) and X-ray structure analysis. The configuration of these compounds strongly depends on solvent, temperature and substitution pattern. Unexpectedly, some of these compounds form weak intramolecular hydrogen bonds/short N{single bond}H⋯F{single bond}C contacts in CDCl3 solution and in the solid state.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalJournal of Fluorine Chemistry
Volume130
Issue number5
DOIs
StatePublished - May 2009

Bibliographical note

Funding Information:
We are grateful to Deutsche Akademische Austauschdienst for financial support, and we thank Dr. Michael Kampf for preparation of 4 .

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • Crystal structures
  • Fluorine substituted benzamides
  • Hydrogen bonds/short contacts
  • NMR investigations
  • Synthesis

Fingerprint Dive into the research topics of 'Fluorine hydrogen short contacts and hydrogen bonds in substituted benzamides'. Together they form a unique fingerprint.

Cite this