Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Angel Tito Alvarado, Ana María Muñoz, María Saravia Bartra, Milton Valderrama-Wong, Daniela González, Luis Abel Quiñones, Nelson Varela, María Rocío Bendezú, Jorge Antonio García, Berta Loja-Herrera

Research output: Contribution to journalArticlepeer-review

Abstract

The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/*2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalPharmacia
Volume68
Issue number4
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
Latin American Society of Pharmacogenomics and Personalized Medicine and Latin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Madrid, Spain.

Publisher Copyright:
© 2021. Alvarado AT et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

  • Allelic variants
  • Mestizo
  • Mutagens
  • Peru
  • Procarcinogens

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