Genetic ancestry of families of putative Inka descent

José R. Sandoval, Daniela R. Lacerda, Marilza S. Jota, Ronald Elward, Oscar Acosta, Donaldo Pinedo, Pierina Danos, Cinthia Cuellar, Susana Revollo, Fabricio R. Santos, Ricardo Fujita

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study focuses on the descendants of the royal Inka family. The Inkas ruled Tawantinsuyu, the largest pre-Columbian empire in South America, which extended from southern Colombia to central Chile. The origin of the royal Inkas is currently unknown. While the mummies of the Inka rulers could have been informative, most were destroyed by Spaniards and the few remaining disappeared without a trace. Moreover, no genetic studies have been conducted on present-day descendants of the Inka rulers. In the present study, we analysed uniparental DNA markers in 18 individuals predominantly from the districts of San Sebastian and San Jerónimo in Cusco (Peru), who belong to 12 families of putative patrilineal descent of Inka rulers, according to documented registries. We used single-nucleotide polymorphisms and short tandem repeat (STR) markers of the Y chromosome (Y-STRs), as well as mitochondrial DNA D-loop sequences, to investigate the paternal and maternal descent of the 18 alleged Inka descendants. Two Q-M3* Y-STR clusters descending from different male founders were identified. The first cluster, named AWKI-1, was associated with five families (eight individuals). By contrast, the second cluster, named AWKI-2, was represented by a single individual; AWKI-2 was part of the Q-Z19483 sub-lineage that was likely associated with a recent male expansion in the Andes, which probably occurred during the Late Intermediate Period (1000–1450 AD), overlapping the Inka period. Concerning the maternal descent, different mtDNA lineages associated with each family were identified, suggesting a high maternal gene flow among Andean populations, probably due to changes in the last 1000 years.

Original languageEnglish
Pages (from-to)873-881
Number of pages9
JournalMolecular Genetics and Genomics
Volume293
Issue number4
DOIs
StatePublished - 1 Aug 2018

Bibliographical note

Funding Information:
Acknowledgements We thank all volunteers who donated their samples to this project. We are also grateful to Rolando Chavarría, Alfredo Ugarte, Raúl Carreño, Luis Lumbreras, Donato Amado, Dan-iela Arteaga, Pedro Paulo R. Vieira, Alberto Salazar, David Soria-Hernanz, Jason Blue-Smith, Spencer Wells and to all fieldwork helpers. This work received funds from the National Geographic Society (The Genographic Project 2.0 grant, entitled Origins and descent of the Inca Empire) and grants from USMP (E10012017010), Peru, FAPEMIG and CNPq from Brazil.

Publisher Copyright:
© 2018, The Author(s).

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Inkas
  • MtDNA
  • Panakas
  • Y chromosome
  • Y-SNPs
  • Y-STRs

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