Genetic markers for preeclampsia in Peruvian women

José Pacheco-Romero, Oscar Acosta Conchucos, Doris Virginia Huerta Canales De Miranda, Santiago Cabrera, Marlene Vargas, Pedro Mascaro, Moisés Huamán, José Sandoval, Rudy López, Julio Mateus, Enrique Gil, Enrique Guevara, Nitza Butrica, Diana Catari, David Bellido, Gina Custodio, Andrea Naranjo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbi-mortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. Objective: To determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6) -174 G/C, IL-1β-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women. Methods: Were included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared. Results: No association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the -174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the -511 C/T polymorphism of the IL-1β gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls. Conclusion: No association was found between the studied genetic markers and preeclampsia. However, in the -174G/C polymorphism of the IL-6 gene, significant differences were found mainly in the GG genotype and G allele.

Original languageEnglish
Pages (from-to)e2014437
JournalColombia Medica
Volume52
Issue number1
DOIs
StatePublished - 26 Feb 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2021 Colombia Medica.

Keywords

  • genetic
  • genetic polymorphisms.
  • genetics
  • interleukine-6
  • Peru
  • polymorphism
  • preeclampsia
  • Pregnant women
  • vascular endothelial growth factor

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