Marcadores genéticos de preeclampsia en mujeres peruanas

Translated title of the contribution: Genetic markers for preeclampsia in peruvian women

José Pacheco-Romero, Oscar Acosta Conchucos, Doris Huerta Canales, Santiago Cabrera Ramos, Marlene Vargas Chávez, Pedro Arnaldo Mascaro Sanchez, Moisés Huamán Guerrero, José Sandoval Paredes, Rudy López Gabriel, Julio Mateus, Enrique Gil Guevara, Enrique Guevara Rios, Nitza Butrica Ferré, Diana Catari Soto, David Bellido Yarlequé, Gina Custodio González, Andrea Naranjo Adonaire

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbimortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. Objective: To determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6)-174 G/C, IL-1β-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women. Methods: Were included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared. Results: No association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the-174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the-511 C/T polymorphism of the IL-1β gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls.

Translated title of the contributionGenetic markers for preeclampsia in peruvian women
Original languageSpanish
Article numbere2014437
JournalColombia Medica
Volume52
Issue number1
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
The authors received funding from the Universidad Nacional de San Marcos, as part of 2012-2017 grants from the Vice- Rectorate for Research.

Publisher Copyright:
© 2021 Universidad del Valle.

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