Geographically targeted interventions versus mass drug administration to control Taenia solium cysticercosis, Peru

Cysticercosis Working Group in Peru

Research output: Contribution to journalArticlepeer-review

Abstract

Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention approaches. For ring screening (RS), participants living near pigs with cysticercosis were screened for taeniasis; identified cases were treated with niclosamide. In ring treatment (RT), participants living near pigs with cysticercosis received presumptive treatment with niclosamide. In mass treatment (MT), participants received niclosamide treatment every 6 months regardless of location. In each approach, half the villages received targeted or mass oxfendazole for pigs (6 total study arms). We noted significant reductions in seroincidence among pigs in all approaches (67.1% decrease in RS, 69.3% in RT, 64.7% in MT; p<0.001), despite a smaller proportion of population treated by targeted approaches (RS 1.4%, RT 19.3%, MT 88.5%). Our findings suggest multiple approaches can achieve rapid control of T. solium transmission..

Original languageEnglish
Pages (from-to)2389-2398
Number of pages10
JournalEmerging Infectious Diseases
Volume27
Issue number9
DOIs
StatePublished - Sep 2021

Bibliographical note

Funding Information:
This research was funded by the US National Institute of Neurologic Disorders and Stroke and the Fogarty International Center of the National Institutes of Health (grant no. R01NS080645). I.W.P. was supported by a Fulbright Fellowship.

Publisher Copyright:
© 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.

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