Guillain–Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1

Luis Jaramillo-Valverde, Kelly S. Levano, Isolina Villanueva, Meylin Hidalgo, Marco Cornejo, Pilar Elena Mazzetti Soler, Mario Cornejo-Olivas, Cesar Sanchez, Julio A. Poterico, Julio Valdivia-Silva, Heinner Guio

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Guillain–Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17, and/or ICAM1 had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018. Methods: A total of nine nonrelated cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17, and ICAM1. Results: We found a significant protective association between heterozygous GA genotype in ICAM1 (241Gly/Arg) and GBS (p '.047). IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls. Conclusion: ICAM1 polymorphisms might be considered as potential genetic markers of GBS susceptibility. Further studies with larger sample size will be required to validate these findings.

Original languageEnglish
Article numbere00960
JournalMolecular genetics & genomic medicine
Volume7
Issue number10
DOIs
StatePublished - 1 Oct 2019
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to all the study participants. This work was supported financially by INBIOMEDIC, Universidad de Huánuco, UTEC, and Gen Lab del Peru.

Publisher Copyright:
© 2019 INBIOMEDIC. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • CD1
  • Guillain-Barre syndrome
  • ICAM1
  • IL-17
  • genetic polymorphism

Fingerprint Dive into the research topics of 'Guillain–Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1'. Together they form a unique fingerprint.

Cite this