Health-Related Quality of Life in Adults with Adolescent- and Adult-onset Systemic Lupus Erythematosus: A Longitudinal Study of a Multiethnic US Cohort (LUMINA LXXXIV)

R. Ezequiel Borgia, Manuel F. Ugarte-Gil, Luis M. Vilá, John D. Reveille, Gerald McGwin, Graciela S. Alarcón

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Abstract

Background/Purpose: The long-term impact of childhood-onset systemic lupus erythematosus on Health-related Quality of Life (HRQoL) in adult SLE patients in comparison to those with adult-onset SLE is unknown. We aim to examine and compare HRQoL trajectories in adults with adolescent- and adult-onset SLE. Methods: Patients enrolled in the LUMINA cohort were included. Adolescent-onset SLE were those diagnosed <24 years of age, and adult-onset SLE otherwise. Sociodemographic, clinical, medications, behavioral/psychological and functioning data were obtained. Longitudinal trajectories of the physical component (PCS) and the mental component (MCS) SF-36 summary scores were compared between the groups using a linear mixed model accounting for time-dependent and independent covariates. Results: 470 SLE patients were included (95 adolescent-onset SLE and 375 adult-onset SLE). The mean age at diagnosis was 19.7 years (SD: 2.8) in the adolescent group and 39.3 years (SD: 11.0) in the adult group. Baseline PCS was higher (better physical functioning) in adolescent- when compared to adult-onset SLE (38.9 vs 34.3 respectively, p<0.001); however, the baseline MCS scores was comparable between the groups (41.4 vs 40.5 respectively, p=0.53). The HRQoL improved equally in both groups with no statistically significant difference within and between the groups (last PCS and MCS mean scores: 43.9 and 45.3 in adolescent-onset SLE; 38.1 and 43 in adult-onset SLE respectively). Conclusions: Adults with adolescent-onset SLE exhibited better physical functioning when compared with the adult SLE group despite more severe disease; noteworthy, HRQoL was below the general US population despite clinically meaningful improvement in HRQoL over time in both groups. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalArthritis Care and Research
DOIs
StateAccepted/In press - 2022
Externally publishedYes

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This article is protected by copyright. All rights reserved.

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