Hyperoxia with 100% oxygen following hypoxia-ischemia increases brain damage in newborn rats

Roberto Shimabuku; Arturo Ota; Sonia Pereyra; Betty Véliz; Edith Paz; Graciela Nakachi; Mario More; Miguel Oliveros

doi:10.1159/000086206

Hyperoxia with 100% oxygen following hypoxia-ischemia increases brain damage in newborn rats

Roberto Shimabuku, Arturo Ota, Sonia Pereyra, Betty Véliz, Edith Paz, Graciela Nakachi, Mario More, Miguel Oliveros

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Abstract

Objective: To describe the effect of reoxygenation with 100% O2 as compared to the effect of room air in newborn rat brains after asphyxia. Methods: Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O2 (hyperoxia group) or 21% O2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus. Results: Rats reoxygenated with 100% O 2 post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxygenated with room air (3 of 24 rats) (χ2 test, p = 0.02). Conclusion: We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats. Copyright © 2005 S. Karger AG.

Original language	American English
Pages (from-to)	168-171
Number of pages	4
Journal	Biology of the Neonate
DOIs	https://doi.org/10.1159/000086206
State	Published - 1 Sep 2005

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title = "Hyperoxia with 100% oxygen following hypoxia-ischemia increases brain damage in newborn rats",

abstract = "Objective: To describe the effect of reoxygenation with 100% O2 as compared to the effect of room air in newborn rat brains after asphyxia. Methods: Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O2 (hyperoxia group) or 21% O2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus. Results: Rats reoxygenated with 100% O 2 post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxygenated with room air (3 of 24 rats) (χ2 test, p = 0.02). Conclusion: We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats. Copyright {\textcopyright} 2005 S. Karger AG.",

author = "Roberto Shimabuku and Arturo Ota and Sonia Pereyra and Betty V{\'e}liz and Edith Paz and Graciela Nakachi and Mario More and Miguel Oliveros",

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doi = "10.1159/000086206",

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AU - Shimabuku, Roberto

AU - Ota, Arturo

AU - Pereyra, Sonia

AU - Véliz, Betty

AU - Paz, Edith

AU - Nakachi, Graciela

AU - More, Mario

AU - Oliveros, Miguel

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Objective: To describe the effect of reoxygenation with 100% O2 as compared to the effect of room air in newborn rat brains after asphyxia. Methods: Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O2 (hyperoxia group) or 21% O2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus. Results: Rats reoxygenated with 100% O 2 post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxygenated with room air (3 of 24 rats) (χ2 test, p = 0.02). Conclusion: We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats. Copyright © 2005 S. Karger AG.

AB - Objective: To describe the effect of reoxygenation with 100% O2 as compared to the effect of room air in newborn rat brains after asphyxia. Methods: Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O2 (hyperoxia group) or 21% O2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus. Results: Rats reoxygenated with 100% O 2 post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxygenated with room air (3 of 24 rats) (χ2 test, p = 0.02). Conclusion: We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats. Copyright © 2005 S. Karger AG.

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JO - Biology of the Neonate

JF - Biology of the Neonate

ER -

Hyperoxia with 100% oxygen following hypoxia-ischemia increases brain damage in newborn rats

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