Identificación y evaluación de transportadores de glucosa SGLT1 y GLUT2 y la incretina GLP-1 en intestino delgado de cuyes (Cavia porcellus)

Translated title of the contribution: Identification and assessment of glucose transporters SGLT1 and GLUT2 and incretin GLP-1 in the small intestine of guinea pigs (Cavia porcellus)

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Abstract

The aim of this study was to identify and assess the presence of glucose transporters SGLT1 and GLUT2 and incretin GLP-1 in the small intestine of guinea pig (Cavia porcellus). Five animals of 90 days old were used. Samples from the duodenum, jejunum and ileum were collected after slaughtering to carry out immunohistochemistry assays. Expression of SGLT1, GLUT2 and GLP-1 was observed in all three portions of the small intestine, where SGLT1 showed the highest expression, with a strong staining intensity in the apical and medium section of the crypt-villus axis. GLUT2 showed a strong staining intensity throughout the crypt-villus axis in the jejunum. GLP-1 expression was indirectly analyzed by calculating the number of L cells per mm2 of intestinal mucosa, resulting that the jejunum had the largest number (8.46 ±1.16 cells/mm2) (p<0.05). The results suggest that SGLT1 glucose transporter would be the most important in the guinea pig, and unlike other species, GLP-1 may be mostly secreted by the jejunum.

Translated title of the contributionIdentification and assessment of glucose transporters SGLT1 and GLUT2 and incretin GLP-1 in the small intestine of guinea pigs (Cavia porcellus)
Original languageSpanish
Pages (from-to)399-405
Number of pages7
JournalRevista de Investigaciones Veterinarias del Peru
Volume23
Issue number4
StatePublished - Dec 2012
Externally publishedYes

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