Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit

R. E. Begue; G. Castellares; Cesar Augusto Cabezas Sanchez; J. L. Sanchez; R. Meza; D. M. Watts; D. N. Taylor

doi:10.1128/iai.63.9.3726-3728.1995

Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit

R. E. Begue, G. Castellares, Cesar Augusto Cabezas Sanchez, J. L. Sanchez, R. Meza, D. M. Watts, D. N. Taylor

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises similar to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America.

Original language	English
Pages (from-to)	3726-3728
Number of pages	3
Journal	Infection and Immunity
Volume	63
Issue number	9
DOIs	https://doi.org/10.1128/iai.63.9.3726-3728.1995
State	Published - 1995
Externally published	Yes

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title = "Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit",

abstract = "Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises similar to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America.",

author = "Begue, {R. E.} and G. Castellares and {Cabezas Sanchez}, {Cesar Augusto} and Sanchez, {J. L.} and R. Meza and Watts, {D. M.} and Taylor, {D. N.}",

year = "1995",

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Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit. / Begue, R. E.; Castellares, G.; Cabezas Sanchez, Cesar Augusto; Sanchez, J. L.; Meza, R.; Watts, D. M.; Taylor, D. N.

In: Infection and Immunity, Vol. 63, No. 9, 1995, p. 3726-3728.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit

AU - Begue, R. E.

AU - Castellares, G.

AU - Cabezas Sanchez, Cesar Augusto

AU - Sanchez, J. L.

AU - Meza, R.

AU - Watts, D. M.

AU - Taylor, D. N.

PY - 1995

Y1 - 1995

N2 - Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises similar to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America.

AB - Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises similar to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America.

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DO - 10.1128/iai.63.9.3726-3728.1995

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C2 - 7642315

AN - SCOPUS:0029095709

VL - 63

SP - 3726

EP - 3728

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 9

ER -

Immunogenicity in Peruvian volunteers of a booster dose of oral cholera vaccine consisting of whole cells plus recombinant B subunit

Abstract

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