Immunotherapy for porcine cysticercosis: Implications for prevention of human disease

Carlton A.V. Evans, Armando Emiliano Gonzalez Zariquiey, Robert H. Gilman, Manuela Verastegui, Hector H. Garcia, Alfonso Enrique Victor Chavera Castillo, Joy B. Pilcher, Victor C.W. Tsang, Maritza Alvarez, César Carcamo, Miguel Castro, Genaro Herrera Fernando Diaz, Olga Li, Manuel Martinez, Elba Miranda, Teresa Montenegro, Jorge Naranjo, Patricia Torres

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Taenia solium cysticercosis is an important cause of human disease in many developing countries, Porcine cysticercosis is a vital link in the transmission of this disease and impairs meat production. A treatment for porcine cysticercosis may be an effective way of preventing human disease that would also benefit pig farmers, facilitating control programs in disease-endemic regions. Previous research suggests that reinfection with cysticercosis or immunotherapy with cysticercal antigens may cause degeneration of cysticerci, potentially curing porcine cysticercosis. Therefore, a blinded, randomized, controlled study to assess the efficacy and safety of immunotherapy in 28 naturally parasitized pigs was performed. Four groups of pigs with similar weights were inoculated twice with membrane-enriched cysticercal antigens (MA), saline, aqueous-soluble crude cysticercal antigens (AA) in adjuvant (Freund's complete then incomplete), or adjuvant alone. Immunotherapy was well tolerated but had no consistent effect on the macroscopic appearance of cysticerci or eosinophil count. Histopathologic findings were variable, with both severe and minimal inflammatory reactions seen in adjacent cysticerci in all pigs. Nine (64%) of 14 pigs given immunotherapy developed new antibody bands on electroimmunotransfer blot compared with one (7%) of 14 control pigs (P < 0.01). Treatment with AA in adjuvant caused a significant increase in the proportion of cysticerci that failed to evaginate and were, therefore, not viable for infecting humans (34% for pigs given AA in adjuvant compared with 10% for adjuvant alone; P < 0.04). Although immunotherapy caused a statistically significant decrease in the viability of cysticerci, this immunologic reaction was not great enough to prevent human disease.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume56
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

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