Impact of pathological features of brain metastases in prognosis

Carlos Arturo Castañeda Altamirano; Miluska Castillo; Luis A. Bernabe; Joselyn Sanchez; Sandro Casavilca; Pamela García-Corrochano; Jaime Ponce; Maria R. Villa-Robles; Carolina Belmar Lopez; Enrique Orrego

doi:10.2217/bmm-2017-0161

Impact of pathological features of brain metastases in prognosis

Carlos Arturo Castañeda Altamirano, Miluska Castillo, Luis A. Bernabe, Joselyn Sanchez, Sandro Casavilca, Pamela García-Corrochano, Jaime Ponce, Maria R. Villa-Robles, Carolina Belmar Lopez, Enrique Orrego

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Patients & methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. Results: Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007). Conclusion: High Ki67 index in brain metastasis carries a worse prognosis.

Original language	English
Pages (from-to)	475-485
Number of pages	11
Journal	Biomarkers in Medicine
Volume	12
Issue number	5
DOIs	https://doi.org/10.2217/bmm-2017-0161
State	Published - May 2018
Externally published	Yes

Bibliographical note

Funding Information:
This study was possible thanks to the use of the Automatic Multispectral Imaging System (Olympus BX63) financed by the Pro-grama Nacional de Innovación para la Competitividad y Productividad (Innovate Peru), under the contract 317-PNICP-EC-2014. The authors would like to express their gratitude to V Flores for his support in staining preparation of tumor sections; and to C Flores for a biostatistics review.

Funding Information:
Informed consent was obtained from each study participant. This study was reviewed and approved by the Instituto Nacional de Enfermedades Neoplasicas Institutional Review Board.

Keywords

brain metastasis
infiltrating lymphocytes
proliferation index
survival

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title = "Impact of pathological features of brain metastases in prognosis",

abstract = "Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Patients & methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. Results: Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007). Conclusion: High Ki67 index in brain metastasis carries a worse prognosis.",

keywords = "brain metastasis, infiltrating lymphocytes, proliferation index, survival",

author = "{Casta{\~n}eda Altamirano}, {Carlos Arturo} and Miluska Castillo and Bernabe, {Luis A.} and Joselyn Sanchez and Sandro Casavilca and Pamela Garc{\'i}a-Corrochano and Jaime Ponce and Villa-Robles, {Maria R.} and Lopez, {Carolina Belmar} and Enrique Orrego",

year = "2018",

month = may,

doi = "10.2217/bmm-2017-0161",

language = "Ingl{\'e}s",

volume = "12",

pages = "475--485",

journal = "Biomarkers in Medicine",

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}

TY - JOUR

T1 - Impact of pathological features of brain metastases in prognosis

AU - Castañeda Altamirano, Carlos Arturo

AU - Castillo, Miluska

AU - Bernabe, Luis A.

AU - Sanchez, Joselyn

AU - Casavilca, Sandro

AU - García-Corrochano, Pamela

AU - Ponce, Jaime

AU - Villa-Robles, Maria R.

AU - Lopez, Carolina Belmar

AU - Orrego, Enrique

PY - 2018/5

Y1 - 2018/5

N2 - Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Patients & methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. Results: Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007). Conclusion: High Ki67 index in brain metastasis carries a worse prognosis.

AB - Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Patients & methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. Results: Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007). Conclusion: High Ki67 index in brain metastasis carries a worse prognosis.

KW - brain metastasis

KW - infiltrating lymphocytes

KW - proliferation index

KW - survival

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U2 - 10.2217/bmm-2017-0161

DO - 10.2217/bmm-2017-0161

M3 - Artículo

C2 - 29697273

AN - SCOPUS:85046846243

SN - 1752-0363

VL - 12

SP - 475

EP - 485

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 5

ER -

Impact of pathological features of brain metastases in prognosis

Abstract

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Keywords

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