Impairment by cyclosporin A of reperfusion-induced arrhythmias

Diana Arteaga; Alberto Odor; Rosa M. López; Gloria Contreras; Julieta Pichardo; Elizabeth García; Alberto Aranda; Edmundo Chávez

doi:10.1016/0024-3205(92)90514-P

Impairment by cyclosporin A of reperfusion-induced arrhythmias

Diana Arteaga, Alberto Odor, Rosa M. López, Gloria Contreras, Julieta Pichardo, Elizabeth García, Alberto Aranda, Edmundo Chávez

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35 Scopus citations

Abstract

This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca²⁺-induced damage of mitochondrial functions.

Original language	English
Pages (from-to)	1127-1134
Number of pages	8
Journal	Life Sciences
Volume	51
Issue number	14
DOIs	https://doi.org/10.1016/0024-3205(92)90514-P
State	Published - 1992
Externally published	Yes

Bibliographical note

Funding Information:
The authors wish to thank Mr. Carlos Amezcua for his technical assistence. This work was partially supported by grant of CONACYT (0047N).

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title = "Impairment by cyclosporin A of reperfusion-induced arrhythmias",

abstract = "This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca2+-induced damage of mitochondrial functions.",

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AU - Arteaga, Diana

AU - Odor, Alberto

AU - López, Rosa M.

AU - Contreras, Gloria

AU - Pichardo, Julieta

AU - García, Elizabeth

AU - Aranda, Alberto

AU - Chávez, Edmundo

PY - 1992

Y1 - 1992

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AB - This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca2+-induced damage of mitochondrial functions.

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SP - 1127

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ER -

Impairment by cyclosporin A of reperfusion-induced arrhythmias

Abstract

Bibliographical note

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