Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte, Abraham J. Vaisberg, Rosario Rojas, Luz Caviedes, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. Hammond

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23 Scopus citations

Abstract

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported. © 2008 American Chemical Society and American Society of Pharmacognosy.
Original languageAmerican English
Pages (from-to)102-105
Number of pages4
JournalJournal of Natural Products
DOIs
StatePublished - 1 Jan 2008

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    Aponte, J. C., Vaisberg, A. J., Rojas, R., Caviedes, L., Lewis, W. H., Lamas, G., Sarasara, C., Gilman, R. H., & Hammond, G. B. (2008). Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants. Journal of Natural Products, 102-105. https://doi.org/10.1021/np070560c