Cinética e avidez de anticorpos (IgG) anti-Toxocara em coelhos experimentalmente infectados com Toxocara canis

Translated title of the contribution: Kinetics and avidity of anti-toxocara antibodies (IgG) in rabbits experimentally infected with toxocara canis

Lundia Luara Cavalcante Bin, Vamilton Alvares Santarém, Cecília Braga Laposy, Guita Rubinsky-Elefant, William Henry Roldán, Rogério Giuffrida

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

An evaluation was made of the kinetics and avidity of anti-Toxocara antibodies (IgG) in rabbits experimentally infected with embryonated Toxocara canis eggs. Seventeen four month old New Zealand White rabbits were distributed into two groups. In the experimental group, twelve rabbits were infected orally with 1,000 embryonated T. canis eggs. A second group (n = 5), uninfected, was used as a control. Serum samples were collected for analysis on days 7, 14, 21, 28 and 60 post-infection (DPI). An indirect ELISA test was performed to evaluate the reactivity index (RI) of IgG anti-T. canis antibodies and to calculate the avidity index (AI). The animals showed seroconversion from the 14th DPI, with high AI (over 50%) except for one animal, which presented an intermediate AI. At 60 DPI, all the animals were seropositive and maintained a high AI. The data indicated that specific IgG antibodies formed early (14 DPI) in rabbits infected with T. canis, with a high avidity index that persisted throughout the course of the infection.

Translated title of the contributionKinetics and avidity of anti-toxocara antibodies (IgG) in rabbits experimentally infected with toxocara canis
Original languagePortuguese
Pages (from-to)99-104
Number of pages6
JournalRevista Brasileira de Parasitologia Veterinaria
Volume25
Issue number1
DOIs
StatePublished - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© 2016, Brazilain Coll Veterinary Parasitology. All rights reserved.

Keywords

  • Antibody avidity
  • ELISA
  • Immune response
  • Toxocariasis

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