Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

Carlos A. Castaneda; Miluska Castillo; Karina Aliaga; Luis A. Bernabe; Sandro Casavilca; Joselyn Sanchez; Carlos A. Torres-Cabala; Henry L. Gomez; Luis Mas; Jorge Dunstan; Jose M. Cotrina; Julio Abugattas; Ivan Chavez; Eloy Ruiz; Paola Montenegro; Victor Rojas; Enrique Orrego; Marco Galvez-Nino; Brayam Felix; Maria P. Landa-Baella; Tatiana Vidaurre; Maria R. Villa; Rocio Zevallos; Luis Taxa; Henry Guerra

doi:10.2217/bmm-2019-0178

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

Carlos A. Castaneda, Miluska Castillo, Karina Aliaga, Luis A. Bernabe, Sandro Casavilca, Joselyn Sanchez, Carlos A. Torres-Cabala, Henry L. Gomez, Luis Mas, Jorge Dunstan, Jose M. Cotrina, Julio Abugattas, Ivan Chavez, Eloy Ruiz, Paola Montenegro, Victor Rojas, Enrique Orrego, Marco Galvez-Nino, Brayam Felix, Maria P. Landa-BaellaTatiana Vidaurre, Maria R. Villa, Rocio Zevallos, Luis Taxa, Henry Guerra

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3⁺, CD4⁺, CD8⁺, CD20⁺, CD68⁺ and CD163⁺ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies.

Original language	English
Pages (from-to)	1481-1491
Number of pages	11
Journal	Biomarkers in Medicine
Volume	13
Issue number	17
DOIs	https://doi.org/10.2217/bmm-2019-0178
State	Published - 2019

Bibliographical note

Funding Information:
This work was partly supported by the Programa Nacional de Innovacion para la Competitividad y Productividad-Innovate Peru (contract no. 317-PNICP-EC-2014), and CONCYTEC (contract no. 197-2015-FONDECYT). The authors have no other relevant

Funding Information:
This work was partly supported by the Programa Nacional de Innovacion para la Competitividad y Productividad-Innovate Peru (contract no. 317-PNICP-EC-2014), and CONCYTEC (contract no. 197-2015-FONDECYT). The authors have no other relevant affiliations or financialinvolvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Publisher Copyright:
© 2019 Future Medicine Ltd.

Keywords

biomarker
cancer
cervix
density
gastric
glioblastoma
lung
lymphocytes
macrophages
melanoma

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Castaneda, C. A., Castillo, M., Aliaga, K., Bernabe, L. A., Casavilca, S., Sanchez, J., Torres-Cabala, C. A., Gomez, H. L., Mas, L., Dunstan, J., Cotrina, J. M., Abugattas, J., Chavez, I., Ruiz, E., Montenegro, P., Rojas, V., Orrego, E., Galvez-Nino, M., Felix, B., ... Guerra, H. (2019). Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies. Biomarkers in Medicine, 13(17), 1481-1491. https://doi.org/10.2217/bmm-2019-0178

@article{186e0dee440e4468b0ba82b5de4ea79a,

title = "Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies",

abstract = "Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies.",

keywords = "biomarker, cancer, cervix, density, gastric, glioblastoma, lung, lymphocytes, macrophages, melanoma",

author = "Castaneda, {Carlos A.} and Miluska Castillo and Karina Aliaga and Bernabe, {Luis A.} and Sandro Casavilca and Joselyn Sanchez and Torres-Cabala, {Carlos A.} and Gomez, {Henry L.} and Luis Mas and Jorge Dunstan and Cotrina, {Jose M.} and Julio Abugattas and Ivan Chavez and Eloy Ruiz and Paola Montenegro and Victor Rojas and Enrique Orrego and Marco Galvez-Nino and Brayam Felix and Landa-Baella, {Maria P.} and Tatiana Vidaurre and Villa, {Maria R.} and Rocio Zevallos and Luis Taxa and Henry Guerra",

note = "Publisher Copyright: {\textcopyright} 2019 Future Medicine Ltd.",

year = "2019",

doi = "10.2217/bmm-2019-0178",

language = "Ingl{\'e}s",

volume = "13",

pages = "1481--1491",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "17",

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Castaneda, CA, Castillo, M, Aliaga, K, Bernabe, LA, Casavilca, S, Sanchez, J, Torres-Cabala, CA, Gomez, HL, Mas, L, Dunstan, J, Cotrina, JM, Abugattas, J, Chavez, I, Ruiz, E, Montenegro, P, Rojas, V, Orrego, E, Galvez-Nino, M, Felix, B, Landa-Baella, MP, Vidaurre, T, Villa, MR, Zevallos, R, Taxa, L & Guerra, H 2019, 'Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies', Biomarkers in Medicine, vol. 13, no. 17, pp. 1481-1491. https://doi.org/10.2217/bmm-2019-0178

TY - JOUR

T1 - Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

AU - Castaneda, Carlos A.

AU - Castillo, Miluska

AU - Aliaga, Karina

AU - Bernabe, Luis A.

AU - Casavilca, Sandro

AU - Sanchez, Joselyn

AU - Torres-Cabala, Carlos A.

AU - Gomez, Henry L.

AU - Mas, Luis

AU - Dunstan, Jorge

AU - Cotrina, Jose M.

AU - Abugattas, Julio

AU - Chavez, Ivan

AU - Ruiz, Eloy

AU - Montenegro, Paola

AU - Rojas, Victor

AU - Orrego, Enrique

AU - Galvez-Nino, Marco

AU - Felix, Brayam

AU - Landa-Baella, Maria P.

AU - Vidaurre, Tatiana

AU - Villa, Maria R.

AU - Zevallos, Rocio

AU - Taxa, Luis

AU - Guerra, Henry

PY - 2019

Y1 - 2019

N2 - Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies.

AB - Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies.

KW - biomarker

KW - cancer

KW - cervix

KW - density

KW - gastric

KW - glioblastoma

KW - lung

KW - lymphocytes

KW - macrophages

KW - melanoma

UR - http://www.scopus.com/inward/record.url?scp=85074446280&partnerID=8YFLogxK

U2 - 10.2217/bmm-2019-0178

DO - 10.2217/bmm-2019-0178

M3 - Artículo

C2 - 31621387

AN - SCOPUS:85074446280

SN - 1752-0363

VL - 13

SP - 1481

EP - 1491

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 17

ER -

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

Abstract

Bibliographical note

Keywords

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