Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru

Alessandro Bartoloni; Lucia Pallecchi; Connie Fernandez; Antonia Mantella; Eleonora Riccobono; Donata Magnelli; Dario Mannini; Marianne Strohmeyer; Filippo Bartalesi; Higinio Segundo; Joaquin Monasterio; Hugo Rodriguez; César Cabezas; Eduardo Gotuzzo; Gian Maria Rossolini

doi:10.1016/j.ijid.2012.11.017

Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru

Alessandro Bartoloni, Lucia Pallecchi, Connie Fernandez, Antonia Mantella, Eleonora Riccobono, Donata Magnelli, Dario Mannini, Marianne Strohmeyer, Filippo Bartalesi, Higinio Segundo, Joaquin Monasterio, Hugo Rodriguez, César Cabezas, Eduardo Gotuzzo, Gian Maria Rossolini

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.

Original language	English
Pages (from-to)	e339-e342
Journal	International Journal of Infectious Diseases
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.ijid.2012.11.017
State	Published - May 2013

Bibliographical note

Funding Information:
This study was supported by the European Commission ALFAII Programme (BACTERIALNET project, contract number AML/19.0901/06/18414/II-0531-FC-FA-FCD-FI) and by grants from the Italian Ministry for Foreign Affairs (‘Fortalecimiento de la red de salud del Chaco Boliviano: una perspectiva comunitaria’), the Ente Cassa di Risparmio di Firenze (Florence, Italy), and the Regione Toscana, Italy (‘Toscana e Chaco, 25 anni di cooperazione sanitaria: un passo decisivo verso il contenimento della diffusione delle resistenze batteriche agli antibiotici’).

Keywords

Bolivia
Community settings
Latin America
MRSA
Nasal carriage
Peru
Staphylococcus aureus

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10.1016/j.ijid.2012.11.017

Cite this

Bartoloni, A., Pallecchi, L., Fernandez, C., Mantella, A., Riccobono, E., Magnelli, D., Mannini, D., Strohmeyer, M., Bartalesi, F., Segundo, H., Monasterio, J., Rodriguez, H., Cabezas, C., Gotuzzo, E., & Rossolini, G. M. (2013). Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru. International Journal of Infectious Diseases, 17(5), e339-e342. https://doi.org/10.1016/j.ijid.2012.11.017

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title = "Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru",

abstract = "Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.",

keywords = "Bolivia, Community settings, Latin America, MRSA, Nasal carriage, Peru, Staphylococcus aureus",

author = "Alessandro Bartoloni and Lucia Pallecchi and Connie Fernandez and Antonia Mantella and Eleonora Riccobono and Donata Magnelli and Dario Mannini and Marianne Strohmeyer and Filippo Bartalesi and Higinio Segundo and Joaquin Monasterio and Hugo Rodriguez and C{\'e}sar Cabezas and Eduardo Gotuzzo and Rossolini, {Gian Maria}",

note = "Funding Information: This study was supported by the European Commission ALFAII Programme (BACTERIALNET project, contract number AML/19.0901/06/18414/II-0531-FC-FA-FCD-FI) and by grants from the Italian Ministry for Foreign Affairs ({\textquoteleft}Fortalecimiento de la red de salud del Chaco Boliviano: una perspectiva comunitaria{\textquoteright}), the Ente Cassa di Risparmio di Firenze (Florence, Italy), and the Regione Toscana, Italy ({\textquoteleft}Toscana e Chaco, 25 anni di cooperazione sanitaria: un passo decisivo verso il contenimento della diffusione delle resistenze batteriche agli antibiotici{\textquoteright}). ",

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Bartoloni, A, Pallecchi, L, Fernandez, C, Mantella, A, Riccobono, E, Magnelli, D, Mannini, D, Strohmeyer, M, Bartalesi, F, Segundo, H, Monasterio, J, Rodriguez, H, Cabezas, C, Gotuzzo, E & Rossolini, GM 2013, 'Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru', International Journal of Infectious Diseases, vol. 17, no. 5, pp. e339-e342. https://doi.org/10.1016/j.ijid.2012.11.017

TY - JOUR

T1 - Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru

AU - Bartoloni, Alessandro

AU - Pallecchi, Lucia

AU - Fernandez, Connie

AU - Mantella, Antonia

AU - Riccobono, Eleonora

AU - Magnelli, Donata

AU - Mannini, Dario

AU - Strohmeyer, Marianne

AU - Bartalesi, Filippo

AU - Segundo, Higinio

AU - Monasterio, Joaquin

AU - Rodriguez, Hugo

AU - Cabezas, César

AU - Gotuzzo, Eduardo

AU - Rossolini, Gian Maria

N1 - Funding Information: This study was supported by the European Commission ALFAII Programme (BACTERIALNET project, contract number AML/19.0901/06/18414/II-0531-FC-FA-FCD-FI) and by grants from the Italian Ministry for Foreign Affairs (‘Fortalecimiento de la red de salud del Chaco Boliviano: una perspectiva comunitaria’), the Ente Cassa di Risparmio di Firenze (Florence, Italy), and the Regione Toscana, Italy (‘Toscana e Chaco, 25 anni di cooperazione sanitaria: un passo decisivo verso il contenimento della diffusione delle resistenze batteriche agli antibiotici’).

PY - 2013/5

Y1 - 2013/5

N2 - Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.

AB - Objective: To investigate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in rural and urban community settings of Bolivia and Peru. Methods: MRSA nasal carriage was investigated in 585 individuals living in rural and urban areas of Bolivia and Peru (one urban area, one small rural village, and two native communities, one of which was highly isolated). MRSA isolates were subjected to molecular analysis for the detection of virulence genes, characterization of the staphylococcal cassette chromosome mec (SCC. mec), and genotyping (multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)). Results: An overall very low prevalence of MRSA nasal carriage was observed (0.5%), with MRSA carriers being detected only in a small rural village of the Bolivian Chaco. The three MRSA isolates showed the characteristics of community-associated MRSA (being susceptible to all non-beta-lactam antibiotics and harboring the SCC. mec type IV), were clonally related, and belonged to ST1649. Conclusions: This study provides an insight into the epidemiology of MRSA in community settings of Bolivia and Peru. Reliable, time-saving, and low-cost methods should be implemented to encourage continued surveillance of MRSA dissemination in resource-limited countries.

KW - Bolivia

KW - Community settings

KW - Latin America

KW - MRSA

KW - Nasal carriage

KW - Peru

KW - Staphylococcus aureus

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U2 - 10.1016/j.ijid.2012.11.017

DO - 10.1016/j.ijid.2012.11.017

M3 - Artículo

C2 - 23266336

AN - SCOPUS:84876095758

SN - 1201-9712

VL - 17

SP - e339-e342

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

IS - 5

ER -

Low prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in urban and rural community settings in Bolivia and Peru

Abstract

Bibliographical note

Keywords

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