Lynch syndrome, Muir Torre variant: 2 cases

María Del Carmen Castro-Mujica, Claudia Barletta-Carrillo, Marisa Acosta-Aliaga, Ximena Montenegro-Garreaud

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Lynch syndrome (LS) is an autosomal-dominant inherited cancer predisposition syndrome caused by germline mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6 or PMS2). Muir-Torre syndrome (MTS) is a phenotypic variant of LS that includes a predisposition to sebaceous glands tumors and keratoacanthomas. We report two patients with MTS, with more than one LS-related cancer, skin lesions, family history of cancer andmicrosatellite instability and immunohistochemistry analysis.
Original languageAmerican English
Pages (from-to)81-85
Number of pages5
JournalRevista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
StatePublished - 1 Jan 2016
Externally publishedYes

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