Magnetic and Mössbauer studies of fucan-coated magnetite nanoparticles for application on antitumoral activity

V. A.J. Silva, P. L. Andrade, Angel Bustamante, L. de los Santos Valladares, M. Mejia, I. A. Souza, K. P.S. Cavalcanti, M. P.C. Silva, J. Albino Aguiar

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4 Scopus citations

Abstract

Fucan-coated magnetite (Fe3O4) nanoparticles were synthesized by the co-precipitation method and studied by Mössbauer spectroscopy and magnetic measurements. The sizes of the nanoparticles were 8-9 nm. Magnetization measurements and Mössbauer spectroscopy at 300 K revealed superparamagnetic behavior. The magnetic moment of the Fe3O4 is partly screened by the Fucan coating aggregation. When the magnetite nanoparticles are capped with oleic acid or fucan, reduced particle-particle interaction is observed by Mössbauer and TEM studies. The antitumoral activity of the fucan-coated nanoparticles were tested in Sarcoma 180, showing an effective reduction of the tumor size. © 2013 Springer Science+Business Media Dordrecht.
Original languageAmerican English
Pages (from-to)227-238
Number of pages12
JournalHyperfine Interactions
DOIs
StatePublished - 1 Jan 2014

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