Malignant lymphoma of the oral cavity and the maxillofacial region: Overall survival prognostic factors

Janet Ofelia Guevara-Canales, Rafael Morales-Vadillo, Sonia Julia Sacsaquispe-Contreras, Carlos Barrionuevo-Cornejo, Jaime Montes-Gil, Carlos Enrique Cava-Vergiú, Fernando Augusto Soares, Henrique Duque de Miranda Chaves-Netto, Maria das Graças Afonso Miranda Chaves

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: To identify the overall survival and prognostic factors of malignant lymphoma of the oral cavity and the maxillofacial region. Study Design: Clinical records data were obtained in order to determine overall survival at 2 and 5 years, the individual survival percentage of each possible prognostic factor with the actuarial technique, and the survival regarding the possible prognostic factors with the actuarial technique and the Log-rank and Cox's regression tests. Results: Of 151 subjects, an overall survival was 60% at 2 years, and 45% at 5 years. The multivariate analysis demonstrated statistically significant differences for clinical stage (p=0.002), extranodal involvement (p=0.030), presence of human immunodeficiency virus (p=0.032), and presence of Epstein-Barr virus (p=0.010). Conclusion: The advanced clinical stage and the larger number of involved extranodular sites are related to a lower overall survival, as well as, the presence of previous infections such as the human immunodeficiency and the Epstein-Barr virus.

Original languageEnglish
Pages (from-to)e619-e626
JournalMedicina Oral, Patologia Oral y Cirugia Bucal
Issue number4
StatePublished - 1 Jul 2013
Externally publishedYes


  • Lymphoma
  • Oral cavity
  • Survival


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