TY - JOUR
T1 - Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection
AU - The WAPM (World Association of Perinatal Medicine) Working Group on COVID-19
AU - Saccone, Gabriele
AU - Sen, Cihat
AU - Di Mascio, Daniele
AU - Galindo, Alberto
AU - Grünebaum, Amos
AU - Yoshimatsu, Jun
AU - Stanojevic, Milan
AU - Kurjak, Asim
AU - Chervenak, Frank
AU - Suárez, María José Rodríguez
AU - Gambacorti-Passerini, Zita Maria
AU - de los Angeles Anaya Baz, María
AU - Galán, Esther Vanessa Aguilar
AU - López, Yolanda Cuñarro
AU - Luis, Juan Antonio De León
AU - Hernández, Ignacio Cueto
AU - Herraiz, Ignacio
AU - Villalain, Cecilia
AU - Venturella, Roberta
AU - Rizzo, Giuseppe
AU - Mappa, Ilenia
AU - Gerosolima, Giovanni
AU - Hellmeyer, Lars
AU - Königbauer, Josefine
AU - Ameli, Giada
AU - Frusca, Tiziana
AU - Volpe, Nicola
AU - Schera, Giovanni Battista Luca
AU - Fieni, Stefania
AU - Esposito, Eutalia
AU - Simonazzi, Giuliana
AU - Di Donna, Gaetana
AU - Youssef, Aly
AU - Gatta, Anna Nunzia Della
AU - Di Donna, Mariano Catello
AU - Chiantera, Vito
AU - Buono, Natalina
AU - Sozzi, Giulio
AU - Greco, Pantaleo
AU - Morano, Danila
AU - Bianchi, Beatrice
AU - Marino, Maria Giulia Lombana
AU - Laraud, Federica
AU - Ramone, Arianna
AU - Cagnacci, Angelo
AU - Barra, Fabio
AU - Gustavino, Claudio
AU - Ferrero, Simone
AU - Ghezzi, Fabio
AU - Huertas, Erasmo
N1 - Publisher Copyright:
© 2020 International Society of Ultrasound in Obstetrics and Gynecology
PY - 2021/2
Y1 - 2021/2
N2 - Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible.
AB - Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible.
KW - COVID-19
KW - SARS-CoV-2
KW - coronavirus
KW - infection
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85100111928&partnerID=8YFLogxK
U2 - 10.1002/uog.23107
DO - 10.1002/uog.23107
M3 - Artículo
AN - SCOPUS:85100111928
SN - 0960-7692
VL - 57
SP - 232
EP - 241
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
IS - 2
ER -