Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Daniela E. Kirwan; Cesar Ugarte-Gil; Robert H. Gilman; Hasan Rizvi; Eduardo Ticona; Gonzalo Chavez; José Luis Cabrera; Eduardo D. Matos; Carlton A. Evans; David A.J. Moore; Jon S. Friedland

doi:10.1128/JCM.02227-15

Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Daniela E. Kirwan, Cesar Ugarte-Gil, Robert H. Gilman, Hasan Rizvi, Eduardo Ticona, Gonzalo Chavez, José Luis Cabrera, Eduardo D. Matos, Carlton A. Evans, David A.J. Moore, Jon S. Friedland

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

© 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Original language	American English
Pages (from-to)	185-189
Number of pages	5
Journal	Journal of Clinical Microbiology
DOIs	https://doi.org/10.1128/JCM.02227-15
State	Published - 1 Jan 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/JCM.02227-15

Cite this

Kirwan, D. E., Ugarte-Gil, C., Gilman, R. H., Rizvi, H., Ticona, E., Chavez, G., Cabrera, J. L., Matos, E. D., Evans, C. A., Moore, D. A. J., & Friedland, J. S. (2016). Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance. Journal of Clinical Microbiology, 185-189. https://doi.org/10.1128/JCM.02227-15

@article{9b0a42b1f01a4e65a0f28bd16dfcc33d,

title = "Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance",

abstract = "{\textcopyright} 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.",

author = "Kirwan, {Daniela E.} and Cesar Ugarte-Gil and Gilman, {Robert H.} and Hasan Rizvi and Eduardo Ticona and Gonzalo Chavez and Cabrera, {Jos{\'e} Luis} and Matos, {Eduardo D.} and Evans, {Carlton A.} and Moore, {David A.J.} and Friedland, {Jon S.}",

year = "2016",

month = jan,

day = "1",

doi = "10.1128/JCM.02227-15",

language = "American English",

pages = "185--189",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

}

TY - JOUR

T1 - Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

AU - Kirwan, Daniela E.

AU - Ugarte-Gil, Cesar

AU - Gilman, Robert H.

AU - Rizvi, Hasan

AU - Ticona, Eduardo

AU - Chavez, Gonzalo

AU - Cabrera, José Luis

AU - Matos, Eduardo D.

AU - Evans, Carlton A.

AU - Moore, David A.J.

AU - Friedland, Jon S.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - © 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

AB - © 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84954316860&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84954316860&origin=inward

U2 - 10.1128/JCM.02227-15

DO - 10.1128/JCM.02227-15

M3 - Article

SN - 0095-1137

SP - 185

EP - 189

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

ER -

Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this