Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Daniela E. Kirwan, Cesar Ugarte-Gil, Robert H. Gilman, Hasan Rizvi, Eduardo Ticona, Gonzalo Chavez, José Luis Cabrera, Eduardo D. Matos, Carlton A. Evans, David A.J. Moore, Jon S. Friedland

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5 Scopus citations

Abstract

© 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.
Original languageAmerican English
Pages (from-to)185-189
Number of pages5
JournalJournal of Clinical Microbiology
DOIs
StatePublished - 1 Jan 2016

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    Kirwan, D. E., Ugarte-Gil, C., Gilman, R. H., Rizvi, H., Ticona, E., Chavez, G., Cabrera, J. L., Matos, E. D., Evans, C. A., Moore, D. A. J., & Friedland, J. S. (2016). Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance. Journal of Clinical Microbiology, 185-189. https://doi.org/10.1128/JCM.02227-15