Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Lymph Node TB Working Group, Peru

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalJournal of Clinical Microbiology
Volume54
Issue number1
DOIs
StatePublished - Jan 2016
Externally publishedYes

Bibliographical note

Funding Information:
Other members of the Lymph Node TB Working Group in Peru include Johnny Ca´rdenas Núñez (Department of Head and Neck Surgery, Hospital Daniel Alcides Carrión, Callao, Peru), Gustavo Cerrillo (Department of Pathology, Hospital Nacional Dos de Mayo, Lima, Peru), Jaime Cok (Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru), Romulo Escobedo (Department of General Surgery, Hospital Nacional Dos de Mayo, Lima, Peru), Margarita Marchino (Department of Head and Neck Surgery, Hospital Nacional Arzobispo Loayza, Lima, Peru), Ernesto Nava (Department of Pathology, Hospital Nacional Arzobispo Loayza, Lima, Peru), and Jose´ Luis Saavedra Leveau (Universidad Nacional Mayor de San Marcos and Department of Head and Neck Surgery, Hospital Nacional Dos de Mayo, Lima, Peru). We are grateful to all of the clinical staff and patients who participated in this study for their collaboration. The views expressed in this report are those of the authors and not necessarily those of the funders. The funders had no role in study design, data collection and analysis, or preparation of the manuscript.Wehave no conflicts of interest to report. This work received financial support from the Sir Halley Stewart Foundation (D.E.K.) and from the International Society for Infectious Diseases via a Small Grant (C.U.-G.). J.S.F. and C.A.E. thank the Imperial College NIHR Biomedical Research Centre for financial support. C.A.E. thanks the JGHT, the Wellcome Trust, IFHAD, and the Bill and Melinda Gates Foundation for funding.

Funding Information:
Other members of the Lymph Node TB Working Group in Peru include Johnny Ca?rdenas N??ez (Department of Head and Neck Surgery, Hospital Daniel Alcides Carri?n, Callao, Peru), Gustavo Cerrillo (Department of Pathology, Hospital Nacional Dos de Mayo, Lima, Peru), Jaime Cok (Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru), Romulo Escobedo (Department of General Surgery, Hospital Nacional Dos de Mayo, Lima, Peru), Margarita Marchino (Department of Head and Neck Surgery, Hospital Nacional Arzobispo Loayza, Lima, Peru), Ernesto Nava (Department of Pathology, Hospital Nacional Arzobispo Loayza, Lima, Peru), and Jose? Luis Saavedra Leveau (Universidad Nacional Mayor de San Marcos and Department of Head and Neck Surgery, Hospital Nacional Dos de Mayo, Lima, Peru). We are grateful to all of the clinical staff and patients who participated in this study for their collaboration. The views expressed in this report are those of the authors and not necessarily those of the funders. The funders had no role in study design, data collection and analysis, or preparation of the manuscript.Wehave no conflicts of interest to report. This work received financial support from the Sir Halley Stewart Foundation (D.E.K.) and from the International Society for Infectious Diseases via a Small Grant (C.U.-G.). J.S.F. and C.A.E. thank the Imperial College NIHR Biomedical Research Centre for financial support. C.A.E. thanks the JGHT, the Wellcome Trust, IFHAD, and the Bill and Melinda Gates Foundation for funding.

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