We have studied the action of an α-latrotoxin (α-LTX) complex of two polypeptides (LTX 130 kDa and low molecular weight protein (LMWP) 8 kDa) and the action of a venom fraction containing LTX with excess LMWP on calcium influx into synaptosomes and PC 12 cells as well as on [14C[GABA release from synaptosomes. Both preparations considerably activate calcium influx and stimulate [14C]GABA release from synaptosomes. Preincubation of both preparations with antibodies against a 14 amino acid residue C-terminal peptide of LMWP differentially modulates these effects. Antibodies inhibit induced calcium influx and enhance induced GABA release. © 1993.
Grishin, E. V., Himmelreich, N. H., Pluzhnikov, K. A., Pozdnyakova, N. G., Storchak, L. G., Volkova, T. M., & Woll, P. G. (1993). Modulation of functional activities of the neurotoxin from black widow spider venom. FEBS Letters, 205-207. https://doi.org/10.1016/0014-5793(93)80803-3