Mortality in hospitalized patients with tuberculous meningitis

Jaime Soria, Tatiana Metcalf, Nicanor Mori, Renee E. Newby, Silvia M. Montano, Luz Huaroto, Eduardo Ticona, Joseph R. Zunt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality. Methods: Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generalized linear regression to identify factors predictive of in-hospital mortality. Results: Of 263 patients, the median age was 35 years, 72.6% were men, 38% were positive for HIV upon admission, 24% had prior TB infections and 2.3% had prior MDR-TB infections. In-hospital mortality was 30.4% of all study patients with a final diagnosis of TBM. When multivariable analysis was applied, significant associations with in-hospital mortality were seen among patients with HIV (RR 2.06; Confidence Interval 95% (95% CI) 1.44-2.94), BMRC II (RR 1.78; 95% CI 1.07-2.97), BMRC III (RR 3.11; 95% CI 1.78-5.45) and positive CSF cultures (RR 1.95; 95% CI 1.39-2.74). Conclusions: In-hospital mortality is higher among patients with HIV infections, age over 40 years, positive CSF TB culture and BMRC stage II or III.

Original languageEnglish
Article number9
JournalBMC Infectious Diseases
Volume19
Issue number1
DOIs
StatePublished - 5 Jan 2019

Bibliographical note

Funding Information:
This project was supported by NIH Research Training Grant # D43 TW009345 funded by the Fogarty International Center, the NIH Office of the Director Office of AIDS Research, the NIH Office of the Director Office of Research on Women's Health, The National Heart, Lung and Blood Institute, the National Institute of Mental Health and the National Institute of General Medical Sciences. The funding agency took no part in study design or analysis of data.

Publisher Copyright:
© 2019 The Author(s).

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • HIV
  • Meningitis
  • Tuberculosis

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