Natural history of experimental pulmonary atelectasis in dogs with closed chest

R. Maxwell, R. López, M. E. Furuya, J. C. Ramírez, U. Beltrán, J. Sandoval, E. Lupi Herrera

Research output: Contribution to journalArticle

Abstract

In order to establish an animal model of pulmonary vasoconstriction we followed the time course of intrapulmonary shunt (Qs/Qt) in a canine model of lobar atelectasis with closed chest. Ten mongrel dogs were studied. Bronchial occlusion of the right lower lobe (RLL) was performed by inflating the balloon of a Foley catheter placed through a rigid bronchoscopy. Analysis of variance was used for statistical analysis. (15 minutes) After occlusion Qs/Qt reached its maximum increasing from 8.2 +/- 3.6 to 29.7 +/- 11.7% (p less than 0.05) and PaO2 decreased from 357 +/- 49 to 100 +/- 43 mm Hg (p less than 0.05). Afterwards, there was a progressive decline of Qs/QT accompanied by an also progressive increase in PaO2. At the end of the experiment (3 hrs post atelectasis) Qs/Qt was 11.2 +/- 4.9 and PaO2 251 +/- 124 mm Hg (p less than 0.05). Pulmonary vascular resistance increased post atelectasis from 439 +/- 168 to 598 +/- 256 d.s.cm-5 (p less than 0.05). Complete atelectasis of the RLL was confirmed postmortem. As the changes in Qs/Qt and PaO2 did not parallel the change in cardiac output we conclude that the mechanism of decrease in Qs/Qt was hypoxic vasoconstriction.
Original languageAmerican English
Pages (from-to)89-93
Number of pages5
JournalArchivos del Instituto de Cardiología de México
StatePublished - 1 Jan 1988
Externally publishedYes

Fingerprint Dive into the research topics of 'Natural history of experimental pulmonary atelectasis in dogs with closed chest'. Together they form a unique fingerprint.

  • Cite this

    Maxwell, R., López, R., Furuya, M. E., Ramírez, J. C., Beltrán, U., Sandoval, J., & Lupi Herrera, E. (1988). Natural history of experimental pulmonary atelectasis in dogs with closed chest. Archivos del Instituto de Cardiología de México, 89-93.