Neoplastic hematological diseases associated with HTLV-1 infection

Carlos Barrionuevo-Cornejo, Daniela Dueñas-Hancco

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Adult cell lymphoma/leukemia (ATLL) is a type of lymphoma consisting of T-cells that are related to infection with the human T lymphotropic virus (HTLV-1). Four clinical forms have been described (leukemic, lymphomatous, chronic, smoldering) and the phenotype corresponds to regulatory CD4+ T cells. The histological characteristics are variable, with neoplastic cells showing a size ranging from small to large and atypical nuclei with irregular contours. A series of genetic and molecular alterations have been described, which partially explain the lymphomagenesis of the neoplasm, some of which are also factors related to the clinical course and overall survival. ATLL is a neoplasm with a poor prognosis, but in recent years new targeted therapies have been designed, with encouraging responses. This neoplasm should continue to be studied to improve treatment and evolution.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalSeminars in Diagnostic Pathology
Issue number2
StatePublished - Mar 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.


  • ATLL
  • Clinical features
  • Histopathology
  • Immunophenotype


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