Neurocysticercosis as a Cause of Epilepsy and Seizures in Two Community-Based Studies in a Cysticercosis-Endemic Region in Peru

Luz M. Moyano, Mayuko Saito, Silvia M. Montano, Guillermo Gonzalvez, Sandra Olaya, Viterbo Ayvar, Isidro González, Luis Larrauri, Victor C.W. Tsang, Fernando Llanos, Silvia Rodríguez, Armando E. Gonzalez, Robert H. Gilman, Hector H. Garcia

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Abstract

Background:The prevalence of epilepsy added to inadequate treatment results in chronic morbidity and considerable mortality in poor populations. Neurocysticercosis (NCC), a helminthic disease of the central nervous system, is a leading cause of seizures and epilepsy in most of the world.Methods:Taking advantage of a cysticercosis elimination program, we performed two community-based cross-sectional studies between 2006 and 2007 in 58 rural communities (population 20,610) to assess the prevalence and characteristics of epilepsy and epileptic seizures in this endemic region. Serological and computed tomography (CT) data in individuals with epilepsy were compared to previous surveys in general population from the same region.Principal findings:In two surveys, 17,450 individuals were evaluated. Lifetime prevalence of epilepsy was 17.25/1000, and prevalence of active epilepsy was 10.8/1000 inhabitants. The prevalence of epilepsy increased after age 25 years and dropped after age 45. Only 24% (45/188) of patients with active epilepsy were taking antiepileptic drugs, all at sub-therapeutic doses. Antibodies to cysticercosis were found in approximately 40% of individuals with epilepsy in both studies. In one survey only individuals presenting strong antibody reactions were significantly associated with having epilepsy (OR 5.74; p<0.001). In the second, the seroprevalence as well as the proportion presenting strong antibody reactions were both significantly higher in individuals with epilepsy (OR 2.2 and 4.33, respectively). Brain CT showed NCC-compatible images in 109/282 individuals with epilepsy (39%). All individuals with viable parasites on CT were seropositive.Conclusion:The prevalence of epilepsy in this cysticercosis endemic region is high and NCC is an important contributor to it.

Original languageEnglish
Article numbere2692
JournalPLoS Neglected Tropical Diseases
Volume8
Issue number2
DOIs
StatePublished - Feb 2014

Bibliographical note

Funding Information:
The authors wish to thank the villagers of all 58 communities involved in the studies and The Regional Directorate of Health-Tumbes. We are grateful to A. Jara, R. Atto, P. Vilchez, S. Mimbela, C. Mendoza, R. Camizan, M. Alvarez, V. Benavides, B. Idrogo, L. Heras, E. Oliva. R. Velasquez and R. Gamboa, the village health personnel and all the field workers of the Cysticercosis Working Group in Tumbes, Peru. LM wants to thank the support and guidance received from the faculty and fellow students of the program Masters in Epidemiological Research from Universidad Peruana Cayetano Heredia and the U.S. Naval Medical Research Unit Six, Lima, Peru. LM wants to thank the support and guidance received from Dr. J. R. Zunt (Department of Global Health, University of Washington).

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