Neurocysticercosis: Unraveling the nature of the single cysticercal granuloma

H. H. García, A. E. Gonzalez, S. Rodriguez, V. C.W. Tsang, E. J. Pretell, I. Gonzales, R. H. Gilman

Research output: Contribution to journalScientific review

47 Scopus citations

Abstract

A single enhancing lesion in the brain parenchyma, also called an inflammatory granuloma, is a frequent neurologic diagnosis. One of the commonest causes of this lesion is human neurocysticercosis, the infection by the larvae of the pork tapeworm, Taenia solium. Following the demonstration that viable cysticercosis cysts survive in good conditions for several years in the human brain, single cysticercal granulomas have been consistently interpreted as representing late degeneration of a long-established parasite. On the basis of epidemiologic, clinical, and laboratory evidence detailed in this article, we hypothesize that in most cases these inflammatory lesions correspond to parasites that die in the early steps of infection, likely as the natural result of the host immunity overcoming mild infections. Copyright © 2010 by AAN Enterprises, Inc. All rights reserved.
Original languageAmerican English
Pages (from-to)654-658
Number of pages5
JournalNeurology
DOIs
StatePublished - 17 Aug 2010

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    García, H. H., Gonzalez, A. E., Rodriguez, S., Tsang, V. C. W., Pretell, E. J., Gonzales, I., & Gilman, R. H. (2010). Neurocysticercosis: Unraveling the nature of the single cysticercal granuloma. Neurology, 654-658. https://doi.org/10.1212/WNL.0b013e3181ed9eae