Oxfendazole as successful treatment of Taenia hydatigena metacestodes in naturally infected pigs

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Abstract

The efficacy of oxfendazole (OFZ) on Taenia hydatigena metacestodes, also called Cysticercus tenuicollis ( C. tenuicollis), was studied in 648 raising pigs. This study was performed in Tumbes Department in Peru, an endemic area for cysticercosis. Pigs were randomized in two groups; untreated group (. n = 142) did not receive any treatment and treated group ( n = 506) received OFZ treatment at a single dose of 30 mg/kg body weight. Six months after treatment, the pigs were necropsied. The prevalence of infection by C. tenuicollis among the pigs was 27.5% (39/142) and 2.0% (10/506) in untreated and treated groups, respectively. Untreated group was infested only with viable cysts, whereas treated group had no viable cysts. All the cysts found in treated group presented degeneration, with a thick membrane, and they contained milky fluid and fibrous tissue. A single dose of OFZ was effective against C. tenuicollis, thus providing an alternative drug for controlling this parasite in pigs.

Original languageEnglish
Pages (from-to)971-973
Number of pages3
JournalAsian Pacific Journal of Tropical Biomedicine
Volume5
Issue number11
DOIs
StatePublished - 2015
Externally publishedYes

Bibliographical note

Funding Information:
Partial support from the Fogarty International Center/NIH (training grants D43 TW008273-03 and D43 TW001140) is acknowledged. Luis Antonio Gomez-Puerta's PhD study is supported by the Fogarty International Center/NIH (D43 TW008273-03). Hector Hugo Garcia is supported by a Welcome Trust Senior International Research Fellowship in Public Health and Tropical Medicine.

Keywords

  • Cysticercus tenuicollis
  • Oxfendazole
  • Taenia hydatigena
  • Treatment

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