Parametrial involvement in cervical cancer ib1 patients treated with radical hysterectomy in Peru

Carlos Urrutia, Carlos Santos, Albert Zevallos, Aldo López, Absalón Montoya, Marco Sánchez, Henry Valdivia, Carlos Velarde, Raúl Mantilla, Esperanza Milla, Carlos Castañeda, Mayer Zaharia, Manuel Álvarez

Research output: Contribution to journalArticle

Abstract

© 2014, Instituto Nacional de Salud. All rights reserved. Objectives. To assess the frequency and factors associated with parametrial involvement (PI) in patients with cervical cancer IB1 who underwent radical hysterectomy (RH) at the National Institute of Neoplastic Diseases in Peru. Materials and methods. Cross-sectional study of 214 patients with cervical cancer IB1 undergoing RH with pelvic lymphadenectomy between 2007 and 2012. The population was compared with and without clinicopathological variables associated with PI such as age, tumor size, depth of infiltration, histological grade and pelvic lymph node involvement. Results. Ten patients (4.6%) had PI. Multivariate analysis showed that the depth of invasion (OR 8.37, 95% CI 1.24-56.41, p=0.029) and pelvic node involvement (OR 18.03; 95% CI 3.30-98.44, p=0.001) were all independent predictors of PI. The presence of tumor size ≤ 2 cm, invasion ≤ 10 mm, absence of lymphovascular permeation and absence of nodal involvement identified 97 patients at low risk of PI, none of whom had PI pathology. Conclusions. We confirmed the low frequency of PI in the cervical cancer IB1 subgroup and its association with the depth of invasion and lymph node involvement suggested in previous studies. This information will allow the identification of a subgroup of patients at low risk of PI for less radical surgery in our institution.
Original languageAmerican English
Pages (from-to)431-436
Number of pages6
JournalRevista Peruana de Medicina Experimental y Salud Publica
StatePublished - 1 Jan 2014
Externally publishedYes

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    Urrutia, C., Santos, C., Zevallos, A., López, A., Montoya, A., Sánchez, M., Valdivia, H., Velarde, C., Mantilla, R., Milla, E., Castañeda, C., Zaharia, M., & Álvarez, M. (2014). Parametrial involvement in cervical cancer ib1 patients treated with radical hysterectomy in Peru. Revista Peruana de Medicina Experimental y Salud Publica, 431-436.