© 2019 by Advance Scientific Research. This is an open-access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) Parkinson’s disease is a genetically heterogeneous, idiopathic and metacentric neurodegenerative disease of the nervous system characterized by progressive generalized slowing movements like bradykinesia, weakness, tremor, and rigidity, and postural instability in along with Parkinson’s disease has been pondered to be a non-genetic distemper. A different way, features are associated such as sleep dysfunction, loss of smell, mood disorder, constipation, excessive salivation, and excessive periodic limb movements in sleep. Feudatory factors encompass head injury, pesticide exposure, and agriculture background. Results with development and assembling of αsynuclein in the central nervous system in the substantia nigra. A little while back, in North American, Parkinson’s disease is a significant relationship indicated to 39.5cM of chromosome 2 (2q36-37; PARK11) portion on the deep arm. Immune-related disorder, notably Crohn’s and leprosy diseases are also associated with Parkinson’s disease, however around 15% persona with Parkinson’s disease have primary level correlative who has the distemper in the genes including LRRK2, SNCA, last one GBA found as a keek part for sporadic Parkinson’s disease.