Peripheral CD4+CD28null T-cells as predictors of damage in systemic lupus erythematosus patients

Manuel Francisco Ugarte Gil, César Sánchez-Zúñiga, Rocio V. Gamboa-Cardenas, Madeley Aliaga-Zamudio, Francisco Zevallos, Ana Mosqueira-Riveros, Mariela Medina-Chinchón, Giannina Tineo-Pozo, Claudia Elera-Fitzcarrald, Victor Pimentel-Quiroz, Omar Sarmiento-Velasquez, Cristina Reátegui-Sokolova, Jorge M. Cucho-Venegas, José Alfaro-Lozano, Zoila Rodriguez-Bellido, Cesar Augusto Pastor Asurza, Graciela S. Alarcón, Risto Perich-Campos

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

OBJECTIVES: To determine whether the CD4+CD28null T-cells subpopulation predicts the occurrence of damage in SLE. METHODS: This longitudinal study was conducted in consecutive SLE patients seen every six months in our Rheumatology Department since 2012. Patients in whom CD4+CD28null T-cells had been measured and who had at least one subsequent visit were included in the study. Survival analyses (univariable and multivariable Cox-regression models) were performed to determine the risk of overall and domain damage (as per the SLICC Damage Index - SDI) as a function of the frequency of this T-cell subpopulation. The multivariable model was adjusted for pertinent confounders. All analyses were performed using SPSS 21.0. RESULTS: One hundred and nineteen patients were evaluated; their mean (SD) age was 43.5 (11.9) years, 113 (95.0%) were female. Disease duration was 7.8 (7.0) years, the SLEDAI 5.3 (4.1) and the SDI 1.0 (1.4). The percentage of CD4+CD28null T-cells was 17.4 (14.0). The mean follow-up was 2.1 (0.8) years, and the mean number of visits per patient 3.5 (1.1). Forty-six (38.7%) patients increase at least one SDI point. In the univariable and multivariable analyses, the percentage of CD4+CD28null predicted the occurrence of lung damage [HR: 1.042 (CI95%: 1.001-1.085); p=0.047 and HR: 1.099 (CI95%1.020-1.184); p=0.013, respectively] but neither the total SDI score nor all other SDI domain scores were predicted by the percentage of CD4+CD28null cells. CONCLUSIONS: In SLE patients, CD4+CD28null T-cells predict the occurrence of new lung damage, independently of other risk factors but not of overall damage or damage on other domains.

Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalClinical and Experimental Rheumatology
Volume36
Issue number6
StatePublished - 1 Nov 2018
Externally publishedYes

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