Polymer-based microfluidic devices for rare cell detection by ultrasounds

Gonzalez Itziar, V. Acosta, M. Tijero, J. Berganzo, A. Castillejo, Luis Soto Soto, A. Martin, M. Bouali

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A low-cost technological approach based on the strategic application of ultrasonic waves on polymeric chips has been developed to detect and extract circulating tumor cells from peripheral blood samples flowing through the microfluidic device, which are delivered viable for later biomolecular analyses. This free-label technique can be used as an early detection system to identify metastasis in the initial stages, assuming a very low number of rare cells present in the blood sample, less than 5 cells/7.5mL. We have demonstrated the feasibility of separation of the tumor cells utilizing hydrodynamic forces induced by ultrasounds in polymeric chips delivering viable single cells and multicellular clusters which differentially experience a drift motion as they flow through a microchannel in a sample containing white blood cells.

Original languageEnglish
Title of host publicationIEEE SENSORS 2013 - Proceedings
PublisherIEEE Computer Society
ISBN (Print)9781467346405
DOIs
StatePublished - 2013
Externally publishedYes
Event12th IEEE SENSORS 2013 Conference - Baltimore, MD, United States
Duration: 4 Nov 20136 Nov 2013

Publication series

NameProceedings of IEEE Sensors

Conference

Conference12th IEEE SENSORS 2013 Conference
Country/TerritoryUnited States
CityBaltimore, MD
Period4/11/136/11/13

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