Polyphenol-rich extract of Zhenjiang aromatic vinegar ameliorates high glucose-induced insulin resistance by regulating JNK-IRS-1 and PI3K/Akt signaling pathways

Ting Xia, Wenhui Duan, Zhujun Zhang, Bin Fang, Bo Zhang, Bicheng Xu, Celia Bertha Vargas de la Cruz, Hesham El-Seedi, Jesus Simal-Gandara, Shaoyun Wang, Min Wang, Jianbo Xiao

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Zhenjiang aromatic vinegar is a famous traditional fermented cooking ingredient in China, with multiple nutritional and medicinal applications. Zhenjiang aromatic vinegar extract (100–400 μg/mL) is rich in polyphenols increased the glucose uptake and glucose consumption in high glucose-induced insulin resistant HepG2 (IR-HepG2) cells. Zhenjiang aromatic vinegar extract enhanced glycogen synthesis and attenuated gluconeogenesis by regulating key enzymes in IR-HepG2 cells. In addition, Zhenjiang aromatic vinegar extract ameliorated high glucose-induced IR by inhibiting phosphorylated insulin receptor substrate-1 (IRS-1) expression and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells. Moreover, Zhenjiang aromatic vinegar extract reduced reactive oxygen species generation and phosphorylated c-Jun NH2 terminal kinase (JNK) expression in IR-HepG2 cells. The attenuation of the high glucose is owned to the PI3K/Akt pathway activation, glycogen synthesis induction and gluconeogenesis suppression in IR-HepG2 cells.

Original languageEnglish
Article number127513
JournalFood Chemistry
Volume335
DOIs
StatePublished - 15 Jan 2021
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the National Key R&D Program of China (2016YFD0400505), Tianjin Municipal Education Commission ( TD13-5013 ), special fund of Ningxia Zhongning Wolfberry Industrial Innovation Institute (ZNGQCX-B-2019001), Ningxia Talents Project, and Open Project Program of State Key Laboratory of Food Nutrition and Safety.

Keywords

  • HepG2 cells
  • Insulin resistance
  • JNK-IRS-1
  • PI3K/Akt
  • Polyphenols
  • Vinegar extract

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