Porcine cysticercosis: Possible cross-reactivity of taenia hydatigena to GP50 antigen in the enzyme-linked immunoelectrotransfer blot assay

Claudio Muro, Luis A. Gomez-Puerta, Robert H. Flecker, Ricardo Gamboa, Percy Vilchez Barreto, Pierre Dorny, Victor C.W. Tsang, Robert H. Gilman, Armando E. Gonzalez, Hector H. Garcia, Seth E. O'Neal

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions.Weinvestigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6-8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigenametacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 crossreactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis.

Original languageEnglish
Pages (from-to)1830-1832
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume97
Issue number6
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
Financial support: This research was made possible with support from the Fogarty International Center (FIC) and the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) grant number R21AI119438. Partial support from Training grant TW001140 from the Fogarty International Center in training of study team members is also acknowledged.

Publisher Copyright:
© 2017 by The American Society of Tropical Medicine and Hygiene.

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