Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom

Francisco S. Schneider, Maria C. Starling, Clara G. Duarte, Ricardo Machado de Avila, Evanguedes Kalapothakis, Walter Silva Suarez, Benigno Tintaya, Karin Flores Garrido, Silvia Seraylan Ormachea, Armando Yarleque Chocas, César Bonilla, Carlos Chávez-Olórtegui

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities.

Original languageEnglish
Pages (from-to)1018-1021
Number of pages4
JournalToxicon
Volume60
Issue number6
DOIs
StatePublished - Nov 2012
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil – CAPES (TOXINOLOGIA No 23038000825/2011-63 ), Fundação de Amparo a Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG) and by funds of the INCTTOX PROGRAM of Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq). The authors gratefully acknowledge the financial support and assistance of the Instituto Nacional de Salud (Lima, Peru) without which it would not have been possible to carry out this study. We would like to express our gratitude to Dr. Michael Richardson and Jessica McCormack for revising this manuscript.

Keywords

  • Andean snake
  • Anti-venom
  • Bothrops andianus
  • Toxicity
  • Venom

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