Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

G. D. Laing; A. Yarleque; A. Marcelo; E. Rodriguez; D. A. Warrell; R. D.G. Theakston

doi:10.1016/j.toxicon.2004.03.020

Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

G. D. Laing, A. Yarleque, A. Marcelo, E. Rodriguez, D. A. Warrell, R. D.G. Theakston

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Toxicon
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.toxicon.2004.03.020
State	Published - Jul 2004

Bibliographical note

Funding Information:
The authors gratefully acknowledge the financial support, advice and assistance of the British Council (Lima) without which it would not have been possible to carry out this study.

Keywords

In vitro tests
In vivo tests
Peru
South American antivenoms
World Health Organization

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10.1016/j.toxicon.2004.03.020

Cite this

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abstract = "World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.",

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AU - Rodriguez, E.

AU - Warrell, D. A.

AU - Theakston, R. D.G.

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AB - World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

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Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

Abstract

Bibliographical note

Keywords

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