Prioritisation of potential drug targets against bartonella bacilliformis by an integrative in-silico approach

Mariella Farfán-López, Abraham Espinoza-Culupú, Ruth Hortensia Garcia De La Guarda, Federico Serral, Ezequiel Sosa, María Mercedes Palomino, Darío A.Fernández Do Porto

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND Carrion’s disease (CD) is a neglected biphasic illness caused by Bartonella bacilliformis, a Gram-negative bacteria found in the Andean valleys. The spread of resistant strains underlines the need for novel antimicrobials against B. bacilliformis and related bacterial pathogens. OBJECTIVE The main aim of this study was to integrate genomic-scale data to shortlist a set of proteins that could serve as attractive targets for new antimicrobial discovery to combat B. bacilliformis. METHODS We performed a multidimensional genomic scale analysis of potential and relevant targets which includes structural druggability, metabolic analysis and essentiality criteria to select proteins with attractive features for drug discovery. FINDINGS We shortlisted seventeen relevant proteins to develop new drugs against the causative agent of Carrion’s disease. Particularly, the protein products of fabI, folA, aroA, trmFO, uppP and murE genes, meet an important number of desirable features that make them attractive targets for new drug development. This data compendium is freely available as a web server (http://target.sbg.qb.fcen.uba.ar/). MAIN CONCLUSION This work represents an effort to reduce the costs in the first phases of B. bacilliformis drug discovery.

Original languageEnglish
Article numbere200184
Pages (from-to)1-11
Number of pages11
JournalMemorias do Instituto Oswaldo Cruz
Volume115
Issue number7
DOIs
StatePublished - 2020
Externally publishedYes

Bibliographical note

Funding Information:
Financial support: Vicerrectorado de Investigaci?n y Posgrado, UNMSM (Grant n? B19100091).

Keywords

  • Bartonella bacilliformis
  • Carrion’s disease
  • Drug targets
  • Metabolic networks
  • Structurome

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