© 2019 Universidad Nacional Mayor de San Marcos. All rights reserved. The aim of this study was to evaluate the effect of dietary supplementation with sodium butyrate (BS) on productive performance in fattening Guinea pigs. Fifty 14-21 days old weaned male Guinea pigs were randomly distributed in five treatments (0, 100, 200, 300 ppm of BS, 200 ppm of Zn-Bacitracin). Body weight gain, feed consumption and feed conversion were evaluated 70 days after supplementation. No response patterns were detected due to BS or Zn-Bacitracin treatments. It is concluded that, under the experimental conditions, supplementation with BS did not improve the productive parameters evaluated.