Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer

Carlos A. Castaneda; Raymundo Flores; Katerin Y. Rojas; Miluska Castillo; Ketty Dolores-Cerna; Claudio Flores; Carolina Belmar-Lopez; Esperanza Milla; Henry Gomez

doi:10.2217/cns.15.5

Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer

Carlos A. Castaneda, Raymundo Flores, Katerin Y. Rojas, Miluska Castillo, Ketty Dolores-Cerna, Claudio Flores, Carolina Belmar-Lopez, Esperanza Milla, Henry Gomez

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

AIM: This retrospective study determined features associated with brain metastasis (BM) in women with breast cancer.

PATIENTS & METHODS: A total of 215 initially early breast cancer cases were included. We reviewed files and CT scan images of BM.

RESULTS: Median age was 47 years and most of our cases were stage III (58.6%), grade III (62.8%), ER negative (62.3%) and nonluminal (59.1%). Median survival after BM was 4 months. Nonluminal, extracranial disease, time to CNS shorter than 15 months, >three brain lesions and poor breast-graded prognostic assessment and recursive partitioning analysis scores were associated with shorter survival. Adding extracranial disease to breast-graded prognostic assessment score also predicted survival after BM. Radiation response was assessed in 57 patients and response tended to be associated with nonluminal phenotype but not with survival.

CONCLUSION: Factors associated with both initial tumor and clinical features at BM time are associated with shorter survival in our Latinas population.

Original language	English
Pages (from-to)	137-145
Number of pages	9
Journal	CNS oncology
Volume	4
Issue number	3
DOIs	https://doi.org/10.2217/cns.15.5
State	Published - 2015

Keywords

CNS metastases
breast cancer
phenotype
prognostic factor

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10.2217/cns.15.5

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title = "Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer",

abstract = "AIM: This retrospective study determined features associated with brain metastasis (BM) in women with breast cancer.PATIENTS & METHODS: A total of 215 initially early breast cancer cases were included. We reviewed files and CT scan images of BM.RESULTS: Median age was 47 years and most of our cases were stage III (58.6%), grade III (62.8%), ER negative (62.3%) and nonluminal (59.1%). Median survival after BM was 4 months. Nonluminal, extracranial disease, time to CNS shorter than 15 months, >three brain lesions and poor breast-graded prognostic assessment and recursive partitioning analysis scores were associated with shorter survival. Adding extracranial disease to breast-graded prognostic assessment score also predicted survival after BM. Radiation response was assessed in 57 patients and response tended to be associated with nonluminal phenotype but not with survival.CONCLUSION: Factors associated with both initial tumor and clinical features at BM time are associated with shorter survival in our Latinas population.",

keywords = "CNS metastases, breast cancer, phenotype, prognostic factor",

author = "Castaneda, {Carlos A.} and Raymundo Flores and Rojas, {Katerin Y.} and Miluska Castillo and Ketty Dolores-Cerna and Claudio Flores and Carolina Belmar-Lopez and Esperanza Milla and Henry Gomez",

year = "2015",

doi = "10.2217/cns.15.5",

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volume = "4",

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TY - JOUR

T1 - Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer

AU - Castaneda, Carlos A.

AU - Flores, Raymundo

AU - Rojas, Katerin Y.

AU - Castillo, Miluska

AU - Dolores-Cerna, Ketty

AU - Flores, Claudio

AU - Belmar-Lopez, Carolina

AU - Milla, Esperanza

AU - Gomez, Henry

PY - 2015

Y1 - 2015

N2 - AIM: This retrospective study determined features associated with brain metastasis (BM) in women with breast cancer.PATIENTS & METHODS: A total of 215 initially early breast cancer cases were included. We reviewed files and CT scan images of BM.RESULTS: Median age was 47 years and most of our cases were stage III (58.6%), grade III (62.8%), ER negative (62.3%) and nonluminal (59.1%). Median survival after BM was 4 months. Nonluminal, extracranial disease, time to CNS shorter than 15 months, >three brain lesions and poor breast-graded prognostic assessment and recursive partitioning analysis scores were associated with shorter survival. Adding extracranial disease to breast-graded prognostic assessment score also predicted survival after BM. Radiation response was assessed in 57 patients and response tended to be associated with nonluminal phenotype but not with survival.CONCLUSION: Factors associated with both initial tumor and clinical features at BM time are associated with shorter survival in our Latinas population.

AB - AIM: This retrospective study determined features associated with brain metastasis (BM) in women with breast cancer.PATIENTS & METHODS: A total of 215 initially early breast cancer cases were included. We reviewed files and CT scan images of BM.RESULTS: Median age was 47 years and most of our cases were stage III (58.6%), grade III (62.8%), ER negative (62.3%) and nonluminal (59.1%). Median survival after BM was 4 months. Nonluminal, extracranial disease, time to CNS shorter than 15 months, >three brain lesions and poor breast-graded prognostic assessment and recursive partitioning analysis scores were associated with shorter survival. Adding extracranial disease to breast-graded prognostic assessment score also predicted survival after BM. Radiation response was assessed in 57 patients and response tended to be associated with nonluminal phenotype but not with survival.CONCLUSION: Factors associated with both initial tumor and clinical features at BM time are associated with shorter survival in our Latinas population.

KW - CNS metastases

KW - breast cancer

KW - phenotype

KW - prognostic factor

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U2 - 10.2217/cns.15.5

DO - 10.2217/cns.15.5

M3 - Artículo

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AN - SCOPUS:85050578443

SN - 2045-0915

VL - 4

SP - 137

EP - 145

JO - CNS oncology

JF - CNS oncology

IS - 3

ER -

Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer

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Keywords

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