Protection against Oxidative Stress and Metabolic Alterations by Synthetic Peptides Derived from Erythrina edulis Seed Protein

Nathaly Rodríguez-Arana, Karim Jiménez-Aliaga, Arturo Intiquilla, José A. León, Eduardo Flores, Amparo Iris Zavaleta, Víctor Izaguirre, Christian Solis-Calero, Blanca Hernández-Ledesma

Research output: Contribution to journalArticlepeer-review


The ability of multifunctional food-derived peptides to act on different body targets make them promising alternatives in the prevention/management of chronic disorders. The potential of Erythrina edulis (pajuro) protein as a source of multifunctional peptides was proven. Fourteen selected synthetic peptides identified in an alcalase hydrolyzate from pajuro protein showed in vitro antioxidant, anti-hypertensive, anti-diabetic, and/or anti-obesity effects. The radical scavenging properties of the peptides could be responsible for the potent protective effects observed against the oxidative damage caused by FeSO4 in neuroblastoma cells. Moreover, their affinity towards the binding cavity of angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) were predicted by molecular modeling. The results demonstrated that some peptides such as YPSY exhibited promising binding at both enzymes, supporting the role of pajuro protein as a novel ingredient of functional foods or nutraceuticals for prevention/management of oxidative stress, hypertension, and metabolic-alteration-associated chronic diseases.

Original languageEnglish
Article number2101
Issue number11
StatePublished - Nov 2022

Bibliographical note

Funding Information:
This work has received financial support from CONCYTEC—Banco Mundial “Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia Tecnología e Innovación Tecnológica” 8682-PE, through its executing unit ProCiencia, through project 042-2018-FONDECYT-BM-IADT-AV and from the Universidad Nacional Mayor de San Marcos (RR N° 05753-R-21 and project A21040081).

Publisher Copyright:
© 2022 by the authors.


  • Erythrina edulis
  • antioxidant activity
  • legume proteins
  • molecular docking
  • multifunctional peptides


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