Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens

Charles G. Gauci, César M. Jayashi, Armando E. Gonzalez, Julia Lackenby, Marshall W. Lightowlers

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in Escherichia coli. The TSOL16, TSOL45-1A and TSOL45-1B recombinant antigens, each consisting of fibronectin type III (FnIII) domain S, were produced as fusion proteins with glutathione S-transferase (GST) and maltose binding protein (MBP). Groups of pigs were immunized twice with the GST fusions of the antigens and boosted a third time with the MBP fusions prior to receiving a challenge infection with T. solium eggs. The TSOL16 antigen was found to be capable of inducing high levels of immunity in pigs against a challenge infection with T. solium. Immunological investigations identified differences in immune responses in the pigs vaccinated with the various antigens. The results demonstrate that the TSOL16 antigen could be a valuable adjunct to current porcine vaccination approaches and may allow the further development of new vaccination strategies against T. solium cysticercosis. © 2012 Elsevier Ltd.
Original languageAmerican English
Pages (from-to)3824-3828
Number of pages5
JournalVaccine
DOIs
StatePublished - 6 Jun 2012

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