Efecto protector del aceite de Sacha inchi (Plukenetía volubilis linneo) en ratas Holtzman con inducción de artritis experimental

Translated title of the contribution: Protective effect of Sacha inchi oil (Plukenetía volubilis linneo) in Holtzman rats with induction of experimental arthritis

María Elena Revilla-Velásquez, Jorge Arroyo-Acevedo, Roberto Chávez-Asmat, Fernanda Chamba-Granda, Hugo Justil-Guerrero

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To demonstrate the protective effect of Sacha inchi oil (SI) in arthritis induced by carrageenan in Holtzman rats. Methods. Quantitative, experimental and correlational study; 30 rats, males, randomly distributed in 5 groups were used: 1) SSF 2 mL/kg; 2) Carrageenan; 3) 4) and 5) Sacha inchi. Except for the control, they received 0.1 mL 2% carrageenan intra-articularly (the area of the femur joint with the left tibia); sacha inchi oil orally 225, 1125 and 2250 mg/kg correspondingly; determining time (seconds), type of grip (normal, poor, regular, moderate, intense), and pannus inflammation, pannus fibrosis by means of histopathological study. Applying analysis of variance, Tukey and Fisher test. Results. There was a higher percentage of dose-dependent anti-inflammatory effect and grasp time at 2250 mg/Kg, followed by 1125 mg/Kg; and the histopathological study showed mild pannus and absent fibrosis with the highest dose, in contrast to doses of 1125 mg/Kg of oil there was moderate pannus, and mild fibrosis. Conclusions. The protective effect of Sacha inchi oil (SI) has demonstrated by increasing the time and improving the type of grasp and reducing the pannus in arthritis induced by carrageenan in Holtzman rats.

Translated title of the contributionProtective effect of Sacha inchi oil (Plukenetía volubilis linneo) in Holtzman rats with induction of experimental arthritis
Original languageSpanish
Pages (from-to)12-18
Number of pages7
JournalAnales de la Facultad de Medicina
Volume83
Issue number1
DOIs
StatePublished - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Fingerprint

Dive into the research topics of 'Protective effect of Sacha inchi oil (Plukenetía volubilis linneo) in Holtzman rats with induction of experimental arthritis'. Together they form a unique fingerprint.

Cite this